KIOS was tested in a one-year study at University of Texas Health Science Center – San Antonio under the direction of Charles L. Bowden, MD, The University of Cincinnati Lindner Center of Hope under the direction of Susan L. McElroy, MD, and the University of Louisville under the direction of Rif S. Al-Mallakh, MD.
In this multi-site study, funded by the National Institute of Mental Health, patients using KIOS experienced a statistically significant reduction in bipolar symptoms over the first sixteen weeks of the study that persisted until the end of the year long trial.